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Adverse pregnancy outcomes (APOs) and periodontal disease: pathogenic mechanisms

Source: J Clin Periodontol (2013)


Periodontal pathogens/byproducts may reach the placenta and spread to the foetal circulation and amniotic fluid. Their presence in the foeto-placental compartment can stimulate a foetal immune/inflammatory response characterized by the production of IgM antibodies against the pathogens and the secretion of elevated levels of inflammatory mediators, which in turn may cause miscarriage or premature birth.


Adverse pregnancy outcomes (APOs) and periodontal disease
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