What Are the Potential Benefits of Using Bacteriophages in Periodontal Therapy?
Periodontitis, which may result in tooth loss, constitutes both a serious medical and social problem. This pathology, if not treated, can...
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Molecular Mechanisms Leading from Periodontal Disease to Cancer
Source: Int. J. Mol. Sci. (2022) Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has...
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The dental plaque biofilm matrix
Source: Periodontol (2000) Advances in deoxyribonucleic acid (DNA) sequencing have given us unprecedented insights into the identity of...
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Survival of Oral Bacteria
Source: Crit Rev Oral Biol Med (1998) The global distribution of individual species of oral bacteria demonstrates their ability to...
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Porphyromonas gingivalis and Treponema denticola synergistic polymicrobial biofilm development
Source: PLoS One (2013) Chronic periodontitis has a polymicrobial biofilm aetiology and interactions between key bacterial species are...
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Nature of the Interplay Between Periodontal Diseases and COVID-19
Source: Front Dent. Med (2021) The coronavirus disease 2019 (COVID-19) is mostly a mild condition, however, in some patients, it could...
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Emerging role of bacteria in oral carcinogenesis:
A review with special reference to perio-pathogenic bacteria Source: Journal of Oral Microbiology (2016) Oral cancer, primarily oral...
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Thyroid-Gut-Axis: How Does the Microbiota Influence Thyroid Function?
Source: Nutrients, (2020) A healthy gut microbiota not only has beneficial effects on the activity of the immune system, but also on...
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A Pilot Study of Integration of Medical and Dental Care in 6 States
Source: CDC, (2021) Poor oral health affects overall health. Chronic diseases and related risk factors such as tobacco use or consuming...
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Dr. Tom Nabors and Steven Anderson Interview
"Aa and Pg set the immune system on fire." -Dr. Tom Nabors Dr. Tom Nabors sat down with Steven Anderson of the Tops Institute to speak...
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Review of Antibiotic Study
Thomas W. Nabors, DDS, FACD (2013) Review of Antibiotic Study "Both antibiotic groups resulted in greater reductions of all clinical...
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Specific Antibiotics in the Treatment of Periodontitis - A Proposed Strategy
Beikler, Prior, Ehmke, Flemmig (2004) "The results of the study indicate that there are at least 46 different combinations of the...
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Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
George Hajishengallis & Triantafyllos Chavakis (2021) "Periodontitis, a major inflammatory disease of the oral mucosa, is...
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The Role of Porphyromonas gingivalis Outer Membrane Vesicles in Periodontal Disease
Zhang et al. (2021) "Colonization by P. gingivalis leads to impaired innate host defense and promotion of inflammation. These alterations...
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High-risk periodontal pathogens contribute to the pathogenesis of atherosclerosis
"Level A evidence supports that Periodontal Disease is independently associated with arterial disease. Studies indicate that the adverse...
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Direct Diagnostics Bibliography for Periodontal Infections
Direct Diagnostics (Current) A comprehensive list of sources on the science behind HR5. Read the full research below.
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Oral Systemic Health is the Future of Healthcare
Advanced saliva testing can innovate your care. Educating your patients on how oral health is connected to the health of the whole body.
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How Well Do You Know the Oral Pathogens?
Over 700 bacteria live in your mouth. Most of these oral bacteria are harmless and some are even beneficial.
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Saliva Testing Provides an Objective Diagnosis for Dental Care
Just 1ml of saliva delivers highly quantitative results on the five bacteria considered to be the highest risk pathogens for periodontitis.
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Meet Direct Diagnostics
Direct Diagnostics is a clinical laboratory and biotechnology company that is advancing the field of molecular testing.
RESEARCH
Below is a curated selection of research papers, journal articles, and other significant publications related to the HR5 pathogens and Oral-Systemic Health.
Research Menu
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