Role of oxyR in the Oral Anaerobe Porphyromonas gingivalis
Source: Journal of Bacteriology (2006) Porphyromonas gingivalis is an anaerobic microorganism that inhabits the oral cavity, where...
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Porphyromonas gingivalis and Treponema denticola synergistic polymicrobial biofilm development
Source: PLoS One (2013) Chronic periodontitis has a polymicrobial biofilm aetiology and interactions between key bacterial species are...
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Treponema denticola chymotrypsin-like proteinase integrates spirochaetes within oral microbial
Source: Microbiology (2012) Treponema denticola is found ubiquitously in the human oral cavity and is mainly associated with bacterial...
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The subgingival microbiome in health and periodontitis
and its relationship with community biomass and inflammation. Source: The ISME Journal (2013) The goals of this study were to better...
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Bacterial sex in dental plaque
Source: Journal of Oral Microbiology (2013) Genes are transferred between bacteria in dental plaque by transduction, conjugation, and...
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Microbial colonization of the periodontal pocket and its significance for periodontal therapy
Source: Periodontology (2000) In classic bacterial infections the diversity of the microbiota decreases as the disease develops; in most...
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Can oral bacteria affect the microbiome of the gut?
Source: Journal of Oral Microbiology (2019) Oral bacteria spreading through the body have been associated with a number of systemic...
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Term stillbirth caused by oral Fusobacterium nucleatum
Obstet Gynecol (2010) Intrauterine infection is a recognized cause of adverse pregnancy outcome but the source of infection is often...
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Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt/β-catenin modulator Annexin A1
Source: EMBO Reports (2019) Colorectal cancer (CRC) is the second leading cause of cancer death in the United States, affecting 1 in 20...
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Emerging role of bacteria in oral carcinogenesis:
A review with special reference to perio-pathogenic bacteria Source: Journal of Oral Microbiology (2016) Oral cancer, primarily oral...
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Periodontal Disease Assessment and Treatment Is an Essential Element in Cardiovascular Wellness
Thomas Nabors, DDS; Bradley Bale, MD; and Amy Doneen, ARNP (2012) "The systemic implications of treating these oral-biofilm infections...
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Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
George Hajishengallis & Triantafyllos Chavakis (2021) "Periodontitis, a major inflammatory disease of the oral mucosa, is...
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The Systemic Effect of Periodontal Therapy on the Management of Diabetes and Heart Disease:
A Review of Recent Studies "The health care fields should recognize that reducing inflammation and chronic infection from the oral...
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Understanding microbial components of periodontal diseases treatment-induced microbiological shifts
Fragkioudakis, et al. Journal of Medical Microbiology 2021; 70:001247: DOI 10. 1099/jmm.0.001247 “Known Putative Pathogens (e.g. Red...
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Oral Systemic Health is the Future of Healthcare
Advanced saliva testing can innovate your care. Educating your patients on how oral health is connected to the health of the whole body.
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How Well Do You Know the Oral Pathogens?
Over 700 bacteria live in your mouth. Most of these oral bacteria are harmless and some are even beneficial.
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Saliva Testing Provides an Objective Diagnosis for Dental Care
Just 1ml of saliva delivers highly quantitative results on the five bacteria considered to be the highest risk pathogens for periodontitis.
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Meet Direct Diagnostics
Direct Diagnostics is a clinical laboratory and biotechnology company that is advancing the field of molecular testing.
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Saliva Testing as the Gold Standard
Interesting Yale Lancet article on the emergence of saliva-based testing as the gold standard for COVID.
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Direct Diagnostics Launches HR5™
The launch of the HR5™ High Risk Pathogen Test is forever changing the Oral-Systemic Health landscape by offering a test that is more...
RESEARCH
Below is a curated selection of research papers, journal articles, and other significant publications related to the HR5 pathogens and Oral-Systemic Health.
Research Menu
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