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Association Between Periodontal Disease and Atherosclerotic Cardiovascular Diseases: Revisited

Atherosclerotic cardiovascular disease (ACVD) is an inflammatory disease of the coronary

arteries associated with atheroma formation, which can cause disability and often death.

Periodontitis is ranked as the sixth most prevalent disease affecting humans affecting

740 million people worldwide. In the last few decades, researchers have focused on the

effect of periodontal disease (PD) on cardiovascular disease. The aim of this review was to

investigate the association between these two diseases. PD is a potential risk factor that

may initiate the development, maturation, and instability of atheroma in the arteries. Two

mechanisms were proposed to explain such association, either periodontal pathogens

directly invade bloodstream or indirectly by increasing systemic level of inflammatory

mediators. Interestingly, it has been suggested that improvement in the condition of one

disease positively impact the condition of the other one. Highlighting the association

between these two diseases, the importance of early diagnosis and treatment of PD and

its impact on cardiovascular status may be of great value in reducing the complications

associated with ACVDs. Further in vitro and in vivo studies with longer follow up are

necessary to confirm the causal relationship between PD and ACVDs.

Foam cell formation- Association Between Periodontal Disease and Atherosclerotic Cardiovas
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