Direct Diagnostics and CRET Partnership Promotes Dental Education Advancements
Through Salivary Diagnostics Direct Diagnostics is thrilled to announce its membership with the Center for Research & Education in...
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Long-term changes in the subgingival microbiota in patients with stage III–IV periodontitis
treated by mechanical therapy and adjunctive systemic antibiotics: A secondary analysis of a randomized controlled trial Aim: To explore...
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Direct Diagnostics Partners with Lincoln Memorial University-College of Dental Medicine
Direct Diagnostics (Direct Dx) is proud to announce their partnership with Lincoln Memorial University-College of Dental Medicine
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Antimicrobial therapy in periodontitis: the use of systemic antimicrobials
Objectives: The aim was to answer three relevant questions: can systemic antimicrobials be efficacious if the biofilm is not disrupted?...
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Systemic antibiotics in periodontal therapy
Periodontitis is a biofilm infection with a mixed microbial aetiology. Periodontitis is generally treated by non-surgical mechanical...
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The Role of Oral Pathobionts in Dysbiosis during Periodontitis Development
Y. Jiao M. Hasegawa and N. Inohara (2014) Direct attack is not the only way that microbes cause disease. Previous studies on infectious...
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Association Between Periodontal Disease and Atherosclerotic Cardiovascular Diseases: Revisited
Atherosclerotic cardiovascular disease (ACVD) is an inflammatory disease of the coronary arteries associated with atheroma formation,...
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Shift in the subgingival microbiome following scaling and root planing
in generalized aggressive periodontitis Guojing Liu, Xiaoqian Yu (2017) Scaling and root planing decreased periodontal pathogens in the...
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Porphyromonas gingivalis: where do we stand in our battle against this oral pathogen?
Kaitlind C. Howard, Octavio A. Gonzalez and Sylvie Garneau-Tsodikova (2021) Periodontal diseases, such as gingivitis and periodontitis,...
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Future Drug Targets in Periodontal Personalized Medicine—A Narrative Review
Periodontal disease is an infection-driven inflammatory disease characterized by the destruction of tooth-supporting tissues. The...
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Active matrix metalloproteinase-8: A potential biomarker of oral systemic link
This mini review aims to address some possible gaps in periodontal diagnosis in clinical studies particularly involving the oral-systemic...
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Molecular Mechanisms Leading from Periodontal Disease to Cancer
Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an...
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The Role of the Oral MicrobiotaRelated to Periodontal Diseases in Anxiety
Anxiety, Mood and Trauma, and Stress-Related Disorders The prevalence of anxiety, mood and trauma-and stress-related disorders are on the...
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The Periodontopathic Pathogen, Porphyromonas gingivalis, Involves a Gut Inflammatory Response
Exacerbates Inflammatory Bowel Disease Periodontal disease (PD) is one of the most prevalent disorders globally and is strongly...
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Prevalence of six periodontal pathogensin subgingival samples of Italian patients
The aim of this study was to investigate the subgingival prevalence of six periodontal pathogens in 352 Italian patients with chronic...
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Yale School of Public Health Verified HR5 Test With 100% Accuracy
Direct Diagnostics, as a transparent, science-based organization, recently submitted our HR5 test—the most accurate test available for...
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Porphyromonas gingivalis-Induced Neuroinflammation in Alzheimer’s Disease
“Chronic” periodontitis and its keystone pathogen Porphyromonas gingivalis have repeatedly been associated with Alzheimer’s disease (AD)....
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Porphyromonas gingivalis and rheumatoid arthritis
Purpose of review: To explore the pathogenic association between periodontal disease and rheumatoid arthritis focusing on the role of...
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Nitrate-responsive oral microbiome modulates nitric oxide homeostasis and blood pressure in humans
Imbalances in the oral microbial community and poor dental health have been associated with reduced cardiovascular and metabolic health....
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Explore the Benefits of Salivary Testing Through Direct Diagnostics
"My career spans 54 years with 2 years in the US Navy and 36 years in private practice. While rotating through dental specialties in the...
RESEARCH
Below is a curated selection of research papers, journal articles, and other significant publications related to the HR5 pathogens and Oral-Systemic Health.
Research Menu
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