The Role of Oral Pathobionts in Dysbiosis during Periodontitis Development
Y. Jiao M. Hasegawa and N. Inohara (2014) Direct attack is not the only way that microbes cause disease. Previous studies on infectious...
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Association Between Periodontal Disease and Atherosclerotic Cardiovascular Diseases: Revisited
Atherosclerotic cardiovascular disease (ACVD) is an inflammatory disease of the coronary arteries associated with atheroma formation,...
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Shift in the subgingival microbiome following scaling and root planing
in generalized aggressive periodontitis Guojing Liu, Xiaoqian Yu (2017) Scaling and root planing decreased periodontal pathogens in the...
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Porphyromonas gingivalis: where do we stand in our battle against this oral pathogen?
Kaitlind C. Howard, Octavio A. Gonzalez and Sylvie Garneau-Tsodikova (2021) Periodontal diseases, such as gingivitis and periodontitis,...
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Future Drug Targets in Periodontal Personalized Medicine—A Narrative Review
Periodontal disease is an infection-driven inflammatory disease characterized by the destruction of tooth-supporting tissues. The...
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Active matrix metalloproteinase-8: A potential biomarker of oral systemic link
This mini review aims to address some possible gaps in periodontal diagnosis in clinical studies particularly involving the oral-systemic...
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Molecular Mechanisms Leading from Periodontal Disease to Cancer
Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an...
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The Role of the Oral MicrobiotaRelated to Periodontal Diseases in Anxiety
Anxiety, Mood and Trauma, and Stress-Related Disorders The prevalence of anxiety, mood and trauma-and stress-related disorders are on the...
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The Periodontopathic Pathogen, Porphyromonas gingivalis, Involves a Gut Inflammatory Response
Exacerbates Inflammatory Bowel Disease Periodontal disease (PD) is one of the most prevalent disorders globally and is strongly...
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Prevalence of six periodontal pathogensin subgingival samples of Italian patients
The aim of this study was to investigate the subgingival prevalence of six periodontal pathogens in 352 Italian patients with chronic...
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Yale School of Public Health Verified HR5 Test With 100% Accuracy
Direct Diagnostics, as a transparent, science-based organization, recently submitted our HR5 test—the most accurate test available for...
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Porphyromonas gingivalis-Induced Neuroinflammation in Alzheimer’s Disease
“Chronic” periodontitis and its keystone pathogen Porphyromonas gingivalis have repeatedly been associated with Alzheimer’s disease (AD)....
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Porphyromonas gingivalis and rheumatoid arthritis
Purpose of review: To explore the pathogenic association between periodontal disease and rheumatoid arthritis focusing on the role of...
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Nitrate-responsive oral microbiome modulates nitric oxide homeostasis and blood pressure in humans
Imbalances in the oral microbial community and poor dental health have been associated with reduced cardiovascular and metabolic health....
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Explore the Benefits of Salivary Testing Through Direct Diagnostics
"My career spans 54 years with 2 years in the US Navy and 36 years in private practice. While rotating through dental specialties in the...
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Efficacy of subgingival irrigation with 10% povidone-iodine as an adjunct to scaling
and root planing: A clinical and microbiological study To evaluate the effectiveness of subgingival irrigation with 10% povidone-iodine...
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Association between tendon ruptures and use of fluoroquinolone
and other oral antibiotics: a 10-year retrospective study of 1 million US senior Medicare beneficiaries Of three fluoroquinolones, only...
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Periodontal Disease: The Good, The Bad, and The Unknown
Source: Frontiers (2021) Periodontal disease is classically characterized by progressive destruction of the soft and hard tissues of the...
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Probiotic bacteria and intestinal epithelial barrier function
Source: Pharmacology, 2020 The intestinal epithelium is in constant contact with luminal contents and the varied, dynamic enteric...
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Survival of Oral Bacteria
Source: Crit Rev Oral Biol Med (1998) The global distribution of individual species of oral bacteria demonstrates their ability to...
RESEARCH
Below is a curated selection of research papers, journal articles, and other significant publications related to the HR5 pathogens and Oral-Systemic Health.
Research Menu