HR5 | Direct Dx

1 min

Porphyromonas gingivalis-Induced Neuroinflammation in Alzheimer’s Disease

“Chronic” periodontitis and its keystone pathogen Porphyromonas gingivalis have repeatedly been associated with Alzheimer’s disease (AD)....

1 min

Rheumatoid Arthritis

Porphyromonas gingivalis and rheumatoid arthritis

Purpose of review: To explore the pathogenic association between periodontal disease and rheumatoid arthritis focusing on the role of...

1 min

Oral Microbiome

Nitrate-responsive oral microbiome modulates nitric oxide homeostasis and blood pressure in humans

Imbalances in the oral microbial community and poor dental health have been associated with reduced cardiovascular and metabolic health....

1 min

News

Explore the Benefits of Salivary Testing Through Direct Diagnostics

"My career spans 54 years with 2 years in the US Navy and 36 years in private practice. While rotating through dental specialties in the...

1 min

Oral Microbiome

Efficacy of subgingival irrigation with 10% povidone-iodine as an adjunct to scaling

and root planing: A clinical and microbiological study To evaluate the effectiveness of subgingival irrigation with 10% povidone-iodine...

1 min

Antibiotics and Probiotics

Association between tendon ruptures and use of fluoroquinolone

and other oral antibiotics: a 10-year retrospective study of 1 million US senior Medicare beneficiaries Of three fluoroquinolones, only...

1 min

Oral Microbiome

Periodontal Disease: The Good, The Bad, and The Unknown

Source: Frontiers (2021) Periodontal disease is classically characterized by progressive destruction of the soft and hard tissues of the...

1 min

Antibiotics and Probiotics

Probiotic bacteria and intestinal epithelial barrier function

Source: Pharmacology, 2020 The intestinal epithelium is in constant contact with luminal contents and the varied, dynamic enteric...

1 min

Oral Microbiome

Survival of Oral Bacteria

Source: Crit Rev Oral Biol Med (1998) The global distribution of individual species of oral bacteria demonstrates their ability to...

1 min

Oral Microbiome

The Role of Hydrogen Peroxide in Environmental Adaptation of Oral Microbial Communities

Source: Oxid Med Cell Longev (2012) Oral bacteria residing in the supragingival biofilm have a remarkable degree of structural...

1 min

Oral Microbiome

Peroxide-Sensing Transcriptional Regulators in Bacteria

Source: J Bacteriol (2012) The ability to maintain intracellular concentrations of toxic reactive oxygen species (ROS) within safe limits...

1 min

Medical-Dental Collaboration

In Sickness and in Health-What Does the Oral Microbiome Mean to Us? An Ecological Perspective

Source: Adv Dent Res, (2019) The oral microbiome is natural, and has a symbiotic relationship with the host by delivering important...

1 min

Medical-Dental Collaboration

Combined effect of arginine and fluoride on the growth of Lactobacillus rhamnosus GG

Source: Scientific Reports, (2021) A homeostatic host-microbe interaction is imperative to effectively maintain or restore health. A...

1 min

Oral Microbiome

Specific Antibiotics in the Treatment of Periodontitis - A Proposed Strategy

Beikler, Prior, Ehmke, Flemmig (2004) "The results of the study indicate that there are at least 46 different combinations of the...

1 min

Oral Microbiome

The Role of Porphyromonas gingivalis Outer Membrane Vesicles in Periodontal Disease

Zhang et al. (2021) "Colonization by P. gingivalis leads to impaired innate host defense and promotion of inflammation. These alterations...

1 min

Cardiovascular

High-risk periodontal pathogens contribute to the pathogenesis of atherosclerosis

"Level A evidence supports that Periodontal Disease is independently associated with arterial disease. Studies indicate that the adverse...

1 min

Oral Microbiome

Understanding the microbial components of periodontal diseases and periodontal treatment

"Periodontitis is now considered to be a multimicrobial inflammatory disease in which the various bacterial species within the dental...

9 min

Interesting Reads

Oral Systemic Health is the Future of Healthcare

Advanced saliva testing can innovate your care. Educating your patients on how oral health is connected to the health of the whole body.

8 min

Interesting Reads

How Well Do You Know the Oral Pathogens?

Over 700 bacteria live in your mouth. Most of these oral bacteria are harmless and some are even beneficial.

8 min

Interesting Reads

Saliva Testing Provides an Objective Diagnosis for Dental Care

Just 1ml of saliva delivers highly quantitative results on the five bacteria considered to be the highest risk pathogens for periodontitis.

RESOURCES

Below is a curated selection of research papers, journal articles, and other significant publications related to the HR5 pathogens and Oral-Systemic Health.

Research Menu